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In tinnitus, abnormal synaptic plasticity leads to enhanced synchronous discharge among neurons in the AC and beyond, cementing the formation of a persistent “tinnitus network” (Kapolowicz and Thompson, 2019)

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For patients who already carry subclinical gut inflammation, the added pharmacological load on the intestinal lining can translate into meaningful discomfort and compromised nutrient absorption during a period when dietary intake is already significantly reduced