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Evidence from large population-based cohorts, national surveys, and observational studies indicates that alterations in menstrual characteristics may occur across diverse populations of reproductive-age women, although the reported prevalence varies substantially because of differences in study design, outcome definitions, follow-up duration, and methods of menstrual assessment (97–104)

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The investigators reported compatibility with Span 60-based niosomes but lower stability in the presence of negatively charged dicetyl phosphate

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