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, prophylactic effect that may only counteract lesion development, but is unable to cure already existing lesions upgraded to the equal therapeutic ability[1])

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Curcumin is often described as a hormetic compound because it induces an adaptive stress response: it mildly stresses cells in ways that activate Nrf2 and other transcription factors, leading to increased production of antioxidant and cytoprotective proteins (e.g., heme oxygenase-1) that precondition cells against subsequent injuries (77, 78)