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Third, although many preclinical studies showed high dose vitamin C could kill cancer cells or retard tumor growth in vivo, vitamin C’s mechanisms of action have not been clear, making it hard to predict the pharmacodynamics, the rational design of combinational therapy, and biomarkers for patient stratification

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Outcomes included THI and VAS scores, as well as serum 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA) levels before and after treatment