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The LEADER trial 28 (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) studied a 1.8-mg dose in more than 9,000 patients with type 2 diabetes and found the incidence of acute pancreatitis was similar between the liraglutide and placebo groups (0.4% vs 0.5%, respectively)

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complicates the simple "VAT reduction" story: investigators reported that the compound appears to improve adipose tissue quality, including measures of fibrosis and adipocyte morphology, somewhat independently of changes in fat quantity (PMID 33756511)