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The HPG axis functions through the pulse production of the gonadotropin-releasing hormone (GnRH) from the hypothalamus, which in the pituitary stimulates the production of the follicle-stimulating hormone (FSH), necessary for sperm production (spermatogenesis), and luteinizing hormone (LH), necessary for both testosterone production and spermatogenesis (11, 15)

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In atopic dermatitis mouse models, AES16-2M administration downregulated disease scores, ear thickness, serum IgE (a key marker of allergic disease), and TSLP