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In this condition, pathological changes in the epiphyseal plate were observed with the decreased expression of COLII and GPX1 in the chondrocytes, suggesting a possible association of reduced chondrocyte anabolism and antioxidant capacity with the epiphyseal plate lesions observed in KBD 72

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· This review covers the development of multi-agonist therapies, including GLP-1–glucagon and GIP–GLP-1–glucagon receptor agonists, which represent a significant advancement in obesity treatment