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5 Clinical features and diagnosis of shingles Symptoms and signs The course of shingles can be divided into three stages: 6 Prodrome (early symptoms stage) – one to four days prior to rash appearing Infectious rash (acute stage) – seven to ten days duration Resolution (healing stage) – two to four weeks duration Prodrome Acute neuralgia is usually the first symptom of shingles and occurs in approximately 70 – 80% of patients