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For weight loss specifically, the regulated, evidence-backed options are the GLP-1 medications semaglutide and tirzepatide, the drug classes studied in the STEP 1 and SURMOUNT-1 trials

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The ambivalence of clinical results may be closely related to several factors: (1) differences in patient staging, as positive trials predominantly included patients with early-stage PD, while negative trials encompassed a broader range of disease stages, where neuronal damage may have become irreversible in late-stage patients (Yoritaka et al., 2018)