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Unlike single-omics studies that merely characterize microbiota or metabolite changes in isolation, integrating 16S rRNA sequencing with untargeted metabolomics allows for the identification of direct “microbiota–metabolite–liver” regulatory cascades, thereby offering novel mechanistic insights that are unattainable with single-omics strategies

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Moreover, H 2 O 2 -triggered lesions on the leaves of cat2 can be reverted by blocking SA synthesis through the isochorismate pathway or by treating leaves with myo -inositol, but in neither case does the suppression of cell death correlate with less oxidized tissue glutathione status (Chaouch and Noctor, 2010