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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations 3-TYP 3-(1H-1,2,3-triazol-4-yl) pyridine A2AR adenosine A2a receptor AMPK adenosine monophosphate protein kinase Bax Bcl-2-associated X protein Bcl-2 B cell lymphoma 2 BLI biolayer interferometry CM-H 2 DCFDA 5-(6)-chloromethyl-2 ′, 7 ′ -dichlorodihydrofluorescein diacetate acetyl ester DMEM Dulbecco’s Modified Eagle’s Medium DMSO dimethyl sulfoxide DPPH 2,2-diphenyl-1-picrylhydrazyl H&E hematoxylin and eosin K D equilibrium dissociation constant MMPs matrix metalloproteinases MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium NAD + nicotinamide adenine dinucleotide PI propidium iodide ROS reactive oxygen species SEM standard error of the mean Sir2 silent information regulator 2 SIRT3 sirtuin 3 SOD2 superoxide dismutase 2 SPR surface plasmon resonance UV ultraviolet

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