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As mentioned before, these were also angiogenesis-promoted in the CAM assay and the tube formation assay and accelerated the blood flow recovery and vessel number in rats with hind limb ischemia [94]

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(2011, American Journal of Pathology) reported that IGF-1 had plaque-stabilizing effects in a mouse atherosclerosis model — useful as a half-life reference (~20-30 hours) and pathway marker