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Furthermore, due to its close interaction with NO-system, as NO acts as an endogenous cardioprotectant antifibrillatory factor [64,65] and BPC 157 has no proarrhytmic effect by itself, BPC 157 might counteract various arrhythmias, including those aggravated by NOS-blockade [66,67,68,69,70,71,72] (note, first communication was about the shortened duration of arrhythmias during hypoxia and the reoxygenation period in isolated guinea pig hearts [73])

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Currently, prodrugs under research comprise TLK286, purine analogs, 77 sulfonamides, 78 and brostallicin