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The short circulating half-life ( t 1/2 ) of native GLP-1 (∼1 minute) makes it unfit as a therapeutic agent, and longer-acting GLP-1RAs with half-lives ranging from ∼2.5 hours to more than a week have been developed for the treatment of both type 2 diabetes and obesity (Table 1) (18)

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doi: 10.1016/S0002-9440(10)63907-7 174 PrusinerS