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Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites α-dihydrotetrabenazine (α-HTBZ) and β-dihydrotetrabenazine (β-HTBZ), with eventual renal elimination of metabolites the α-HTBZ and β-HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent “prodrug” Readily crosses the blood brain barrier & depletes cerebral monoamine stores

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