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Schafer and Buettner (Free Radical Biology and Medicine, 2001) formalised the GSSG/2GSH couple as a quantitative index of the cellular redox environment, a framework still used to describe redox state across proliferation, differentiation and apoptosis in cultured cells

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Aged mice treated with NNMT inhibitors demonstrated approximately 70% greater peak torque (contractile force) in injured muscles compared to untreated controls