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51 The activity of major anti-oxidant enzymes, such as glutathione peroxidase and glutathione reductase, remains normal in Alzheimer's disease, whereas the activity of G6PD and 6-phospho gluconate dehydrogenase increases in inferior temporal cortex of the Alzheimer's brain that results into deregulated (either increased or decreased) Fe 2+ /Ascorbate-induced lipid peroxidation