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These combination approaches aim to enhance tumor immunogenicity through targeted RCD induction, overcome immune evasion mechanisms, and improve the depth and durability of antitumor responses ( 5.1 pharmacological inducers combined with immune checkpoint inhibitors The combination of pharmacological inducers of regulated cell death (RCD), particularly ferroptosis inducers such as RSL3, Erastin, and GPX4 inhibitors, with immune checkpoint inhibitors (ICIs) like anti-PD-1 antibodies, has demonstrated promising synergistic antitumor effects in preclinical melanoma models (126)

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synthesized an aromatic iron-chelator and applied it to mice in which oxidative damage and iron release were induced by a phenylhydrazine treatment