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Additionally, more severe depressive symptoms were correlated with an increased presence of Enterobacteriaceae , while comparatively healthier BD patients had more Clostridiaceae and Roseburia

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1 Introduction Down syndrome (DS) is a genetic disorder mainly associated with intellectual disability, but which also involves a series of clinical conditions that affect multiple body systems, particularly the musculoskeletal, neurological, and cardiovascular systems ( The physical features of DS were first described by John Langdon Down as common characteristics in some children with mental disability ( et al