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Furthermore, Hu et al (42) discovered that the downregulation of the GPX3 gene resulted in a decrease in the wound healing capacity and transmembrane migration rate of OC and colorectal cancer cells

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In summation, alterations in redox balance by exposure to ROS cause dose dependent changes in GSH:GSSG ratios, which can potentially influence a number of target proteins by causing oxidation and disulfide exchange reactions at specific cysteine residues